I året 2021 blev menneskeheden besejret af Gastrea, en parasitiske virus, og er tvunget til at leve inden for en væg lavet af Varanium Monoliths, et metal, der er i stand til at betvinge Gastrea. Snart vil "Forbandet børn", børn født med Gastrea virus, der er i stand til at kontrollere det-som giver dem overmenneskelige evner-blev opdaget. På grund af den Gastrea virus 'indgreb, kunne Forbandet børn kun være kvinde. Borgerlige Securities dannes til at specialisere sig i kampen mod Gastrea, der opererer med parret af en initiator, som er forbandet børn, og en promotor, der tjener til at lede forbandede børn. Ti år efter krigen, Rentarō Satomi, en high school elev, der er også en promotor i sin barndomsven Kisara Tendo s Tendo Civil Security sammen med sin Initator Enju Aihara, modtager en hemmelig mission for at forhindre, at Tokyo-området ødelæggelse.

Like many hardworking members of the workforce, Kuroto Nakano is perpetually stressed out by his job. Still, since he lives alone, he must carry on to sustain himself. Little do humans like Kuroto know, this stress takes the form of darkness residing within a person's body and will bring one's life to ruin. Fox deities can see this darkness and have the duty to save people before it is too late. To help rid Kuroto of his stress, Senko-san, an eight hundred-year-old foxgirl, volunteers to take care of him, and will do everything she can to ease the tension in his weary soul.

High school student Chiyo Sakura has a crush on schoolmate Umetarō Nozaki, but when she confesses her love to him, he mistakes her for a fan and gives her an autograph. When she says that she always wants to be with him, he invites her to his house and has her help on some drawings. Chiyo discovers that Nozaki is actually a renowned shōjo manga artist named Sakiko Yumeno. She then agrees to be his assistant in order to get closer to him. As they work on his manga Let's Fall in Love (恋しよっ), they encounter other schoolmates who assist them or serve as inspirations for characters in the stories.

Our MC finds out that his school requires him to join a club and during his reluctant search he stumbles upon Tejina-senpai attempting magic tricks in her clubroom. Tejina-senpai has massive stage fright however and so now that she has an audience her attempts are simply comedic.

OMG! There’s this girl at school, Yamada, who wants to make like a hundred sex friends. She totally thinks she can devirginize one hundred different boys! Can you believe that? That’s like every boy in the school. Who does she think she is? I heard from my friend’s neighbor’s cousin’s lab partner that Yamada’s never even been kissed. Oh. My. God. I would totally die. That’s like burn all your makeup and shave off your eyebrows embarrassing. I can’t even think about it. Today at lunch I saw Yamada flirting, like for reals flirting, with that geek Kosuda. You know the guy. Photography club, no muscles, boring face, kind of reminds you of a black-and-white movie. Super lame. If Yamada can’t even make the sex with him, she’ll never score a hundred cherry boys. She needs to take like Sex Ed or something because I heard she can’t give it away!

A new school term begins, as does the season of new encounters. As he surveys his class full of couples, Hashiba Jun'ichi's mind is filled with distress as he asks himself, "Why am I still a virgin?!" Having heard from his friends that the easiest way to fulfill his long-standing desire to graduate from the fellowship of virgins is to kowtow to a gal, Jun'ichi does exactly that and asks his classmate Yukana out. And unbelievably, she actually agrees to date him. What will become of Jun'ichi from now on?

Year 198 of the Solar Era in Tokyo, special fire brigades are fighting against a phenomenon called spontaneous human combustion where humans beings are turned into living infernos called "Infernals". While the Infernals are first generation cases of spontaneous human combustion, later generations possess the ability to manipulate flames while retaining human form. Shinra Kusakabe, a youth who gained the nickname Devil's Footprints for his ability to ignite his feet at will, joins the Special Fire Force Company 8 which composes of other flames users as they work to extinguish any Infernals they encounter. As a faction that is creating Infernals appears, Shira begins to uncover the truth behind a mysterious fire that caused the death of his family twelve years ago.

Kisaragi Amatsuyu is invited out alone by the cool beauty upperclassman Cosmos and his childhood friend Himawari. Expecting to hear their confessions, he triumphantly goes to meet each of them in turn. But Cosmos and Himawari both instead confess to Amatsuyu that they like his friend. Amatsuyu fights this lonely battle, but there is another girl who is looking at him. She is a gloomy girl with glasses and braids. Amatsuyu finds that he hates her, because she's always turning her sharp tongue only on him and finding enjoyment in his troubles. But it turns out that she's the only one who actually does like him.

A mecha otaku is reincarnated into another world as Ernesti Echevarria, also known as Eru. In this world, huge humanoid weapons known as Silhouette Knights exist. Dreaming of piloting those robots, Eru and his friends, Archid Olter and Adeltrud Olter, aim to become Knight Runners.

For high school students like Shouichi Kamita, university entrance exams and the future are common concerns. It is also during this time in life that a mysterious emotion that vexes people of all ages may begin to weigh upon one's mind—love. At this point in his teenage years, Shouichi finds three girls he could see himself having a future with: the ever-cheerful Hikari Tsuneki, who teases Shouichi without mercy, but actually has a softer side; the competitive gamer, Tooru Miyamae, who has difficulty communicating with others; and Shouichi's childhood friend, Kyouko Touno, the sometimes immature shoujo manga enthusiast. Seiren follows Shouichi's relationships with these three girls across three separate arcs, as their feelings grow from mutual interest and blossom into something more beautiful.

Shy Natsu awakens as part of a group chosen to ensure the survival of humanity. Together, they have to survive on a changed Earth.

Kiyotaka Ayanokoji has just enrolled at Tokyo Koudo Ikusei Senior High School, where it's said that 100% of students go on to college or find employment. But he ends up in Class 1-D, which is full of all the school's problem children. What's more, every month, the school awards students points with a cash value of 100,000 yen, and the classes employ a laissez-faire policy in which talking, sleeping, and even sabotage are permitted during class. One month later, Ayanokoji, Horikita, and the students of Class D learn the truth of the system in place within their school...

Adachi spends her school days skipping class until she meets fellow delinquent Shimamura and the two become fast friends. Cutting class together deepens their friendship but soon unexpected emotions blossom. As awkwardness and confusion settle in, the two girls travel this sea of emotions without a paddle as they learn about each other’s feelings.

Sorata Kanda, a high school sophomore living in Sakurasou, the den of their academy's problem children, spends his days being dragged around by the strange residents, swearing he's going to escape Sakurasou one day.

This feisty young wizard will stop at nothing to master the spell that saved her life: Explosion! Megumin, the “Greatest Genius of the Crimson Magic Clan,” has chosen to devote her studies to the powerful offensive magic used by her mysterious savior. Then one day, her little sister finds a black kitten in the woods. But this cat isn’t just a new furry friend—she’s the key to awakening a Dark God!

Seiya Kanie, believes that the beautiful but reserved Isuzu Sento has invited him on a date at an amusement park called Amagi Brilliant Park. Much to his chagrin, not only is the location a run-down facility, the supposed date is merely a recruitment tour where Sento and Princess Latifa Fleuranza, the owner of the theme park, ask him to become the park's new manager. Their cause for desperation? As stipulated in a land-use contract, Amagi has less than three months to meet a quota of 500,000 guests, or the park will be closed for good and the land redeveloped by a greedy real-estate company. Seiya is won over by the revelation that Amagi is no ordinary amusement park; many of its employees are mysterious magical beings who live in the human world and are nourished by the energy created by people having fun. Entrusted with the hopes and dreams of this far-off enchanted land, Seiya must now use his many skills to bring Amagi back on its feet, or watch it crumble before his eyes.

At the end of her first year of high school, Futaba Yoshioka suddenly has a chance encounter with her first love, Kou Tanaka. Three years ago, he transferred schools before she was able to say how she felt about him. After meeting each other again, Futaba realizes that he has gone through many changes. He acts more cool and even had his last name changed to Mabuchi. Gradually the two rekindle their love while piecing together what had happened in the time that they were apart.

Shiina Aki is constantly being treated like a girl due to his feminine looks so he decides to move to Tokyo to attend middle school in an attempt to change himself. However what awaits him in his new home, Sunohara-sou, is the kind-hearted caretaker, Sunohara Ayaka. Along with the three female members of Aki's new middle school's student council, Yukimoto Yuzu, Yamanashi Sumire & Kazami Yuri. And so begins Aki's new life in Tokyo living with 4 girls.

Daichi Kakeru is a high school student who has never had a girlfriend. Little did he know that everything was about to change when he bought a melon soda on his way home from school as the can came to life in the form of a girl, whom he calls "Melon".

Yuuichi Katagiri believes that friends are more important than money, but he also knows the hardships of not having enough funds. He works hard to save up in order to go on the high school trip, because he has promised his four best friends that they will all go together. However, after the class' money is all collected, it's stolen! Suspicion falls on two of Yuuichi's friends, Shiho Sawaragi and Makoto Shibe. Soon afterwards, the five of them are kidnapped, and wake up in a strange room with a character from a short-lived anime. Apparently, one of them has entered them into a "friendship game" in order to take care of their massive debt. But who was it, and why did they have such a debt? Could they have stolen the money from class to pay for entry into the game? Yuuichi and his best friends will have to succeed in psychological games that will test or destroy their faith in one another.